Renal disease is unfortunately a common cause of death in dogs and cats and research has shown that the modern pet diet is a major contributor to this pathology. Essentially, it boils down to the ratio of the types of fats found in pet food.
Modern dry pet food is manufactured from refined animal and vegetable proteins. Animal fats, which are mostly made up of saturated fats, are added to make the food better tasting. Plant oils are also added because they supply some essential fatty acids (EFA) that are necessary to a pets diet. Vitamins and minerals are also added and the mixture is either steamed and extruded or baked. This cooking process, in and of itself, is detrimental to the nutritional needs of carnivorous pets (recent studies have established that there seems to be a quality to fresh uncooked and unprocessed meat that is essential to the health and longevity of cats and dogs).
As mentioned before, animal and plant fats are a major ingredient in pet food. These fats provide three polyunsaturated fatty acids (PUFA), arachidonic acid (AA), linoleic acid (LA) and to a lesser extent alpha linolenic acid (ALA). Two of these, AA and LA are n-6 PUFA’s while ALA is an n-3 PUFA. Both types of PUFA’s are converted in the pets body into more complex PUFA’s called eicosanoids.
These eicosanoids are hormone like molecules that have very pronounced effects on the regulation of numerous body functions such as blood pressure, blood viscosity (slipperiness), vasoconstriction (tightening of the arteries), immune and inflammatory responses.
The n-6 eicosanoids have an inflammatory effect, particularly on kidneys. The n-6’s also increase the blood flow to the kidneys causing glomerular hypertension (above normal pressure in the kidney’s filters). The n-3 eicosanoids “exert renoprotective effects, reducing glomerular hypertension, intrarenal inflammation, hyperlipidemia (excess fats in blood), lipid peroxidation (oxygen damage to fats), and intrarenal growth factor elaboration (a scaring type of growth)” according to a study done at the College of Veterinary Medicine at the University of Georgia.
The ratio of n-6 to n-3 fats in a pets (and human) diet has a profound effect on the health of the kidneys. The ideal ratio is approximately 3 to 1 of n-6 to n-3. The typical ratio in most pet’s diets is 15 to 1.
The most abundant source of n-3 eicosanoids is fish oil which contains two forms, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Numerous clinical studies have shown that the importance of DHA and EPA supplementation extend to many aspects of dogs and cats healthy physiology. These range from accelerated cognitive development in puppies and kittens, cardiovascular and renal protective qualities, protection form development of diabetes and obesity, amelioration of inflammatory bowl diseases to many other conditions that have an inflammatory component.
Most renal diseases have an inflammatory component and most renal injury is characterized by infiltration and activation of inflammatory cells. The fish oil eicosanoids stop and actually reverse the inflammation and prevent the formation of scar tissue that destroys normal renal function.
The longer inflammation of the renal tissues lasts the more the likelihood of irreversible damage to the organ. Though chronic renal failure in cats and dogs doesn’t normally present itself before approximately 75% of kidney function is lost, not all this damage is irreversible. As much as 20% of lost renal function can, in certain conditions, be attributed to inflammation that has not caused scarring yet and can, with the appropriate treatment, be recouped.
Another component of chronic renal failure is oxidative stress due to an imbalance between antioxidants and reactive oxygen species (ROS). These ROS’s are continuously formed in the kidney by various cells as part of an unspecific defense system against bacteria and other microbes. These ROS’s also affect host cells, particularly at the site of inflammation. If their formation is not balanced by antioxidants, they can play a significantly detrimental role in CRF, as well as many other types of progressive renal diseases. ROS’s are also implicated in the high blood pressure that most CRF pets eventually suffer from.
Clinical studies have shown that vitamin E supplementation is very effective at neutralizing ROS’s and their inflammatory properties, blocking their oxidation of LDL which is associated with CRF induced atherosclerosis and reducing high blood pressure.
The isoprenoid pathway is also affected in CRF. This pathway produces several key metabolites important in cellular regulation. One of these metabolites is ubiquinone which is a component of the mitochondrial electron transport chain and is also a powerful free radical scavenger. Simply put, ubiquinone plays a crucial role in the energy pathway of the healthy cell. Ubiquinone levels are reduced in pets suffering from crf. Clinical studies have confirmed that supplementation with ubiquinone results in significant improvements in renal function tests and that it imparts a marked renoprotective effect. Studies have shown it to be beneficial in the treatment of congestive heart failure, cardiomyopathies , diabetes and periodontal disease. It also helps preserve vitamin E.
Astro’s CRF Oil
Astro’s CRF Oil is a unique formula created from pharmaceutical grade fish oil with a very high concentration of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) which has been deodorized and micro filtered to remove any heavy metals, vitamin E, which also helps keep the fish oil from oxidizing, and a highly bio-available liquid form of ubiquinone (a higher percentage can be utilized by the body), in concentrations and ratios that are optimal for the treatment of chronic renal failure. This product is totally natural and has no side effects. Administered according to instructions, Astro’s CRF Oil will begin to have noticeable effects within the first 2-4 weeks in most crf pets. It is also a great supplement for healthy pets as it helps protect against many inflammatory diseases. It will give your pet a beautiful coat and will actually stop shedding and skin irritations. It is also recommended for the healthy and precocious mental development (and according to some studies) trainability of puppies and kittens. Kittens in particular will benefit as studies have determined that kittens are in a constant state of DHA deficit.
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ASTRO’S CRF OIL
Feline and Canine CRF can be treated
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